The Annotated Hodgkin and Huxley

The first annotated edition of the scientific papers that created the foundation of modern neuroscience and physiology

The origin of everything known about how neurons and muscles generate electrical signals can be traced back to five revolutionary papers, published in the Journal of Physiology in 1952 by Alan Hodgkin and Andrew Huxley. The principles they revealed remain cornerstones of the discipline, summarized in every introductory neuroscience and physiology course. Since that era, however, scientific practice, technology, and presentation have changed extensively. It is difficult for the modern reader to appreciate Hodgkin and Huxley¿s rigorous scientific thought, elegant experimental design, ingenious analysis, and beautiful writing.

This book provides the first annotated edition of these papers, offering essential background on everything, from terminology, equations, and electronics, to the greater historical and scientific context surrounding t